USE OF SODIUM NITROPRUSSIDE FOR DELIBERATE HYPOTENSION DURING PREGNANCY

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A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children

Sodium nitroprusside (SNP) has been widely used to control blood pressure in infants and children. The goals of this analysis were to develop models that describe the hemodynamic response to SNP dosing in pediatric patients; examine sources of variation in dose-response, defining age, and size dependencies; and determine vulnerable populations or patient subtypes that may elicit dosing modifica...

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Sodium Nitroprusside for Aneurysm Surgery in Pregnancy

A 25-year-old woman in the 7th month of pregnancy was operated upon for a ruptured cerebral aneurysm. Sodium nitroprusside was used to achieve effective controlled hypotension. Signs of foetal distress were transient. Subsequent delivery was spontaneous and uneventful. Development of the child at 2 yr was satisfactory. The various physiological aspects and the action of nitroprusside on both mo...

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Evaluation of sodium nitroprusside for controlled hypotension in children during surgery

PURPOSE (1) To define the onset and offset of the blood-pressure-lowering effects of sodium nitroprusside (SNP) for use in developing instructions for dose titration in children undergoing a surgical or medical procedure, and (2) to assess the safety of SNP administration in pediatric patients requiring controlled reduction of blood pressure. METHODS We conducted a randomized, double-blind, p...

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Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.

In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a s...

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Effect of sodium nitroprusside-induced hypotension on pulmonary deadspace.

Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio ( Vb/ Vr). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase Vb/ VT, and that va...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1981

ISSN: 0007-0912

DOI: 10.1093/bja/53.9.985